李新圃,罗金印,武小虎,李宏胜,丁学智

• 1:中国农业科学院兰州畜牧与兽药研究所农业农村部兽用药物创制重点实验室/甘肃省中兽药工程技术研究中心

摘要(Abstract)：

金黄色葡萄球菌(金葡菌)具有极强的致病性和耐药性,这与它易于形成生物膜密切相关。金葡菌生物膜的形成,最初认为与多糖细胞间黏附素(PIA)有关,但进一步研究发现,即使没有PIA,金葡菌也可以利用细胞壁锚定蛋白(CWA)形成生物膜。根据研究数据,可以将生物膜形成过程分为4个阶段:初始附着、细胞聚集、生物膜成熟、生物膜分散。金葡菌生物膜的形成主要受群体感应(QS)系统调控,该系统涉及各种调控因子,研究较多的有辅助基因调节子(Agr)、葡萄球菌附属调节子(Sar)、转录因子Sigma B(SigB)和信号传导系统(LuxS/AI-2)。这些调控因子不仅具有各自的调控系统,而且相互协同和制约,共同调节金葡菌生物膜的形成和毒素的释放,与金葡菌的耐药性和致病性密切相关。通过对QS系统及其调控因子的靶向干预,有望找到防控金葡菌感染的新途径。本综述归纳总结了金葡菌生物膜的形成及调控机制研究进展,以期为进一步深入研究提供参考。

关键词(KeyWords)： 金黄色葡萄球菌;生物膜;耐药性;致病性

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划资助项目(2017YFD0502200);; 甘肃省国际科技合作计划资助项目(17YF1WA169);; 中国农业科学院奶牛疾病研究创新工程资助项目(CAAS-ASTIP-2014-LIHPS-03)

作者(Author): 李新圃,罗金印,武小虎,李宏胜,丁学智

DOI: 10.16303/j.cnki.1005-4545.2021.10.30

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